Thins most epoxies, fiberglass resins and specialty coatings. P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. The effects of methyl-n-butyl-ketone (591786) (MBK) and methyl-ethyl-ketone (78933) (MEK) on the peripheral nerves of rats were studied. Methyl nonyl ketone was determined to be relatively immobile in sodium azide-sterilized sandy loam, clay loam, sand, and silt loam soils and does not hydrolyze. Methyl ethyl ketone (MEK), also known as butanone, is an organic compound with the molecular formula CH3C (O)CH2CH3. It is a colorless liquid with a sharp, sweet odor. Other Effects f Methyl Ethyl Ketone Peroxide can irritate the lungs. Remove grossly contaminated clothing. Skin Exposure: Wash thoroughly with water. 4. Klean Strip Methyl Ethyl Ketone MEK SAFETY DATA SHEET Supersedes Revision: 03/26/2015 CAS # Hazardous Components (Chemical Name) 15. P264 Wash skin thoroughly after handling. It is produced industrially on a large scale, and also occurs in trace amounts in nature. PDF Material Safety Data Sheet Section 1. Chemical Product and ... Gas concentrations are in percent by volume. Nearly half of it is used in paints and other coatings because it will quickly evaporate. TECHNICAL REPORT DATA ffteme irtd Instructions on the rtvtrte btfort completing) 1. May be ignited by heat, sparks or flame and undergoes self-accelerating decomposition. Methyl ethyl ketone: health effects and incident management. Inhalation: Can irritate the nose and throat. They were exposed to a mixture of solvents including toluene (geometric mean 18 ppm), methyl ethyl ketone (MEK; 16 ppm), isopropyl alcohol (IPA; 7 ppm), and ethyl acetate (9 ppm). Eye Exposure: Hold eyelids open and flush with a steady, gentle stream of water for at least 15 minutes. PDF Methyl Ethyl Ketone Page 3 - Health Hazard Evaluation Determination 73-72 Substances Methyl Ethyl Ketone Methyl Isobutyl Ketone Toluene N-Buytyl Acetate Xylene Cyclohexanone 8-Hour-Time-Weightid Average PPM* 200 100 200 150 100 50 *Parts of vapor or gas per mil 1 ion parts of contaminated air by volume at 25°C and 760 mm H~ pressure .. HAZARDS IDENTIFICATION This material is considered to be hazardous according to regulat ory guidelines (see MSDS Section 15). Long term health effects. Toxicity Summary. PB90142456. It is not intended to be a comprehensive treatise on the chemical or toxicological nature of methyl ethyl ketone. What are the potential health effects of methyl ethyl ketone? The worldwide effects of the Covid infection 2020 (COVID-19) are now beginning to be felt, and will essentially influence the Methyl Ethyl Ketone (MEK) market in 2020 and 2021. 42. 15 While the association between benzene and leukaemia is well established, other solvent effects, such as those on the nervous system, are more . EPA/60Q/8-89/093 3. Updated Health Effects Assessment For Methyl Ethyl Ketone. Information on methyl ethyl ketone (MEK) (also known as 2-butanone), for use in responding to chemical incidents. The intensity was mostly below unity using the additiveness formula based on current Japanese occupational exposure limits, but more than eight times unity at the . METHYL ETHYL KETONE 78 -93 -3 100% * All concentrations are percent by weight unless material is a g as. EPA has classified methyl ethyl ketone as a Group D, not classifiable as to human carcinogenicity. Acute, but high concentrations, of MEK can result in irritation to the eyes, nose and throat. If irritation or redness develops, seek medical attention. Overview Health effects Environmental effects Sources of emissions References Description Methyl ethyl ketone is used as a solvent for lacquers, adhesives, cleaning materials to be electroplated, degreasing, rubber and rubber cement, printing inks, and paints, wood stains and varnishes, paint removers, in cleaning solutions, as a catalyst, and as a carrier. 2-Butanone is a manufactured organic chemical. . Repeated exposure may cause bronchitis to develop with coughing, phlegm, and/or shortness of breath. The Health and Environmental Effects Profile for methyl ethyl ketone was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response to support listings of hazardous constituents of a wide range of waste streams under Section 3001 of the Resource Conservation and Recovery Act . It is an isomer of another solvent . SECTION 1 Identification of the substance/mixture and of the company/undertaking Acute (short-term) inhalation exposure to methyl ethyl ketone in humans results in irritation to the eyes, nose, and throat. MEK is also a common solvent that can be formulated into other products or purchased at full strength. Anmol Chemicals Group, established in 1976, is the pioneer manufacturer of Specialty chemicals, Pharmaceutical Excipients, Fragrance & Flavor chemicals in India.Anmol Chemicals Group has manufacturing facilities spread across Western India, representatives in Houston . P271 Use only outdoors or in a well-ventilated area. Publication Date. (METHYL ETHYL KETONE (MEK)) PAGE 4 of 10 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION OCCUPATIONAL EXPOSURE LIMITS HAZARDOUS INGREDIENT PEL TLV-TWA Methyl ethyl ketone (MEK) 200 ppm 200 ppm EXPOSURE CONTROLS: Good general ventilation (typically 10 air changes per hour) should be used. 2 (H225) Eye Irrit. Methyl ethyl ketone (MEK) is an organic solvent used throughout the paint and print industry. REASON FOR CITATION * Methyl Ethyl Ketone is on the Hazardous Substance List because it is regulated by OSHA and cited by . Compendium of Chemical Hazards: Methyl Ethyl Ketone Page 8 of 14 Incident Management Health Effects Major route of exposure inhalation, ingestion and skin contact Immediate signs or symptoms of acute exposure Route Signs and symptoms Inhalation Inhalation of high concentrations may cause respiratory irritation and chest tightness. Methyl acetate will likely work well in replacing methyl ethyl ketone (MEK) for removing oils from siliconebased elastomer parts. A total of 137 volunteers were recruited and tested for neurobehavioural performance before, during, and after a short duration (4 h) exposure to acetone at 250 ppm, methyl ethyl ketone (MEK) at 200 ppm, acetone at 125 ppm with MEK at 100 ppm, or a placebo. IDENTIFICATION Methyl Ethyl Ketone is a colorless liquid with a fragrant, mint-like odor. IDENTIFICATION AND USE: Methyl ethyl ketone (MEK) is a colorless liquid with acetone-like odor. It is used as a solvent and in making plastics, textiles, and paints. 2 (H319) STOT SE 3 (H336) (EUH066) Health hazards Serious Eye Damage/Eye Irritation Category 2 (H319) Specific target organ toxicity - (single exposure) Category 3 (H336) Environmental hazards Based on available data, the classification criteria are not met Reference Dose for Chronic Oral Exposure (RfD) Substance Name — Methyl ethyl ketone (MEK) CASRN — 78-93-3 Last Revised — 09/26/2003 The oral Reference Dose (RfD) is based on the assumption that thresholds exist for certain toxic effects such as cellular necrosis. The 2.0% group also showed a reduction in the mean body weight per pup at day 4 following culling (9.48 g vs. This dialkyl ketone is a colourless liquid that has a sharp and sweet odour. Exposure of rats to methyl ethyl ketone at a level of 200 ppm, 12 hours/ day, 7 days/week for 24 weeks resulted 1n slight neurological effects visible only at 4 months of treatment (Takeuchl et al., 1983), but exposure of rats to 1125 ppm continuously for 5 months did not result In neuropathy, defined 1n terms of paralysis (Salda et al., 1976). It can also be present in the environment from natural sources. It can be harmful to the eyes, skin, and if inhaled or swallowed. Page Count. Acute Effects [3] Severity of symptoms depend on the level and type of exposure. Methyl ethyl ketone (MEK) MEK, also known as 2-butanone, is a liquid solvent used in surface coatings, adhesives, printing inks, chemical intermediaries, magnetic tapes and lube oil dewaxing agents. In this research, 137 volunteers were recruited and tested for neurobehavioral performance changes and biochemical indicators during and after a short-duration (4-h) exposure to either acetone at 250 ppm, methyl ethyl ketone (MEK) at 200 ppm, acetone at 125 ppm with MEK at 100 ppm, or a chemical-placebo. (9) Methyl ethyl ketone is also referred to as 2-butanone. I.A. It is also Notwithstanding . To scientifically substantiate the standards, a study was conducted on three groups of workers to … Because MEK reduced the clearance of methyl n-butyl ketone, it is reasonable that an exposure of rats to 1125-ppm MEK and 225-ppm methyl n-butyl ketone, 24 h/d for 35 or 55 d resulted in more severe nerve injuries than an exposure to methyl n-butyl ketone alone at 225 ppm (Saida et al., 1976). Notwithstanding . The Office of Emergency and Remedial Response (Superfund) uses . MEK is an aliphatic ketone. Product Name: Methyl Ethyl Ketone (MEK) Other Names: Ethyl Methyl Ketone, 2-Butanone, Butanone Recommended use: Industrial Chemical, paint and ink manufacture Chemical Family: Oxygenated hydrocarbon Company Name: Solvent Supplies Limited Address: 33 Miro Street, Otaki, New Zealand Fax: 04 902 1857 Email: ss1994ltd@gmail.com Serious health effects in animals have been seen only at very high levels. It occurs in nature in a small amount. 2-Butanone is also called methyl ethyl ketone. Compendium of Chemical Hazards: Methyl Ethyl Ketone Page 8 of 14 Incident Management Health Effects Major route of exposure inhalation, ingestion and skin contact Immediate signs or symptoms of acute exposure Route Signs and symptoms Inhalation Inhalation of high concentrations may cause respiratory irritation and chest tightness. Main Routes of Exposure: Inhalation. Ketones, such as methyl ethyl ketone depress the central nervous system, irritate the eyes and upper respiratory tract. with methyl isobutyl ketone and heptane . Physical / Chemical properties Methyl ethyl ketone peroxide (MEKP) is a mixture of isomers (monomer and dimer) and is marketed exclusively with various stabilizing agents that cannot be totally separated due to Wistar-rats inhaled 60 to 1050 parts per million (ppm) of MBK or 1460 to 4740ppm of MEK for 6 hours per day, 5 days per week for 4 to 6 weeks; rats were exposed to MBK until overt signs of neuropathy were evident. The Health and Environmental Effects Profile for methyl ethyl ketone was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response to support listings of hazardous constituents of a wide range of waste streams under Section 3001 of the Resource Conservation and . a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays . No smoking. Methyl ethyl ketone, mixt. Product identifier Product name METHYL ETHYL KETONE TECH Product number 2723 REACH registration number 01-2119457290-43-XXXX CAS number 78-93-3 EU index number 606-002-00-3 EC number . Methyl ethyl ketone is not thought to be a cancer causing chemical. Methyl Ethyl Ketone (Butanone) - Methyl Ethyl Ketone is an organic compound also known as Butanone or Methylacetone with the chemical formula C4H8O. Background According to section 39655 of the California Health and Safety Code, a toxic air contaminant (TAC) is "an air pollutant which may cause or contribute to an increase in mortality or an increase in serious illness, or which may pose a present or potential hazard to human health." In addition, substances which have been listed as federal hazardous air pollutants (HAPs) pursuant to Butanone is a constituent of tobacco smoke. It is an irritant, causing irritation to the eyes and nose of humans. Does methyl ethyl ketone affect pregnancy or the unborn child? Seek medical attention. Material Safety Data Sheet. Cancer . It is made by some trees and found naturally in some fruits and vegetables in small amounts. FIRST AID MEASURES. A number of long term adverse effects of solvents have been described including leukaemia in benzene exposed workers, 13 scleroderma 14 (mixed solvents), and renal cancer in those exposed to chlorinated hydrocarbons. f Methyl Ethyl Ketone Peroxide may cause a skin allergy. It is listed as a hazardous chemical by the United States Environmental Protection Agency but the neuropsychological and neuropathic effects from exposure are reported variously. INTRODUCTION The Health Advisory (HA) Program, sponsored by the Office of Drinking Water (ODW), provides information on the health effects, analytical method- ology and treatment technology that would be useful in dealing with the contamination of drinking water. The report summarizes and evaluates information relevant to a preliminary interim assessment of adverse health effects associated with specific chemicals or compounds. Methyl Ethyl Ketone Peroxide 1338-23-4 484 mg/kg 200 ppm/4hr Dimethyl Phthalate 131-11-3 6800 mg/kg Cat 9300 mg/m3/6.5 hr Proprietary Phlegmatizer proprietary >3200 mg/kg Human 50 mg/kg eye, nose, and pulmonary effects Methyl Ethyl Ketone 78-93-3 2,737 mg/kg 23,500 mg/m3/8 hr Carcinogenicity: See Cancer Information, Section 3. Workers may be harmed from exposure to methyl ethyl ketone. Butanone (methyl ethyl ketone, MEK) 5 Initial discussions about a health monitoring program should include: possible health effects from exposure to butanone how to recognise and report symptoms, and what is involved in the health monitoring program, for example the frequency of testing and the tests that may be needed.
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